Neuropathy Associated With Gluten Sensitivity.

Neuropathy Link To Gluten Sensitivity

There is an ever growing body of research that links Peripheral Neuropathy with gluten sensitivity. I see this and treat these patients daily in my office. I know the devastating affects that gluten induce neuropathy can bring. That is why in my clinic we test for these and other "initiators" of neuropathy, so that we can get to the root cause of our patients peripheral neuropathy.

As you can see from this study, 80% of the neuropathy positive participants had associated sub-clinical Celiac disease.

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Neuropathy associated with gluten sensitivity.

Neuropathy PMID: 16835287 Jul 2006

J Neurol Neurosurg Psychiatry. 2006 Nov;77(11):1262-­?6. Epub 2006 Jul 11.

Hadjivassiliou M, Gru?newald RA, Kandler RH, Chattopadhyay AK, Jarratt JA, Sanders DS, Sharrack B, Wharton SB, Davies-­?Jones GA.

Source

Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK. m.hadjivassiliou@sheffield.ac.uk

Abstract

OBJECTIVES:

To prospectively study the clinical, neurophysiological and neuropathological characteristics of axonal neuropathies associated with positive antigliadin antibodies and the prevalence of such neuropathies in a cohort of patients with sporadic axonal neuropathy.

METHODS:

Prospective screening (using antigliadin, antiendomysium and tissue transglutaminase antibodies) of patients with peripheral neuropathy attending a neurology clinic.

RESULTS:

215 patients with axonal neuropathy were screened. 141 patients had symmetrical sensorimotor neuropathy, 47 had mononeuropathy multiplex, 17 had motor neuropathy and 10 had small-fibre neuropathy. Despite extensive investigations of the 215 patients, 140 had idiopathic neuropathy.

This compares with 12% prevalence of these antibodies in the healthy controls. The prevalence of coeliac disease as shown by biopsy in the idiopathic group was at least 9% as compared with 1% in the controls. The clinical features of 100 patients (47 from the prevalence study and 53 referred from elsewhere) with gluten neuropathy included a mean age at onset of 55 (range 24-77) years and a mean duration of neuropathy of 9 (range 1-33) years.

CONCLUSIONS:

Gluten sensitivity may be causally linked to a substantial number of idiopathic axonal neuropathies, such as Peripheral Neuropathy.

Positive immunoglobulin (Ig)G with or without IgA antigliadin antibodies was found in 34% (47/140) of the patients with idiopathic neuropathy.

This compares with 12% prevalence of these antibodies in the healthy controls.

The prevalence of coeliac disease as shown by biopsy in the idiopathic group was at least 9% as compared with 1% in the controls.

The clinical features of 100 patients (47 from the prevalence study and 53 referred from elsewhere) with gluten neuropathy included a mean age at onset of 55 (range 24-­77) years and a mean duration of neuropathy of 9 (range 1-­33) years.

Gluten-­sensitive enteropathy was present in 29% of patients.

The human leucocyte antigen types associated with coeliac disease were found in 80% of patients.

neuropathy